Cardiac xenotransplantation: from concept to clinic

B Reichart, DKC Cooper, M Längin… - Cardiovascular …, 2022 - academic.oup.com
For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Heart transplantation: focus on donor recovery strategies, left ventricular assist devices, and novel therapies

MG Crespo-Leiro, MR Costanzo… - European heart …, 2022 - academic.oup.com
Heart transplantation is advocated in selected patients with advanced heart failure in the
absence of contraindications. Principal challenges in heart transplantation centre around an …

Feasibility and potential impact of heart transplantation from adult donors after circulatory death

S Madan, O Saeed, SJ Forest, DJ Goldstein… - Journal of the American …, 2022 - jacc.org
Background A shortage of donation after brain death (DBD) donors for heart transplantation
(HT) persists. Recent improvements in organ procurement from donation after circulatory …

Heart transplantation from DCD donors in Australia: lessons learned from the first 74 cases

Y Joshi, S Scheuer, H Chew, MR Qiu, C Soto… - …, 2023 - journals.lww.com
Heart transplantation from donation after circulatory death (DCD) donors has the potential to
substantially increase overall heart transplant activity. The aim of this report is to review the …

Heart transplantation: Advances in expanding the donor pool and xenotransplantation

S Jou, SR Mendez, J Feinman, LR Mitrani… - Nature Reviews …, 2024 - nature.com
Approximately 65 million adults globally have heart failure, and the prevalence is expected
to increase substantially with ageing populations. Despite advances in pharmacological and …

[HTML][HTML] Current status and outcomes in heart transplantation: a narrative review

MA Awad, A Shah, BP Griffith - Reviews in Cardiovascular Medicine, 2022 - imrpress.com
The first human heart transplantation was performed by Christian Barnard in 1967. While the
technical aspect had been worked out, allograft rejection was a major limitation in the early …

Donation after circulatory death in heart transplantation: history, outcomes, clinical challenges, and opportunities to expand the donor pool

LK Truby, S Casalinova, CB Patel, R Agarwal… - Journal of Cardiac …, 2022 - Elsevier
Heart transplantation remains the gold-standard therapy for end-stage heart failure; the
expected median survival range is 12–13 years. More than 30,000 heart transplants have …

Heart transplantation from donation after circulatory death: Impact on waitlist time and transplant rate

YK Gernhofer, QM Bui, JJ Powell, PM Perez… - American Journal of …, 2023 - Elsevier
The effect of using donation after circulatory death (DCD) hearts on waitlist outcomes has
not been substantiated. We retrospectively analyzed 184 heart transplant (HT) candidates at …

Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell‐Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after …

Z Zeng, L Xu, Y Xu, Y Ruan, D Liu, J Li… - Stem Cells …, 2022 - Wiley Online Library
Objective. Adopting hearts from donation after circulatory death (DCD) is a promising
approach to enlarge the donor pool. Nevertheless, DCD hearts experience severe warm …

Association of procurement technique with organ yield and cost following donation after circulatory death

SS Bakhtiyar, TE Maksimuk, J Gutowski, SY Park… - American Journal of …, 2024 - Elsevier
Donation after circulatory death (DCD) could account for the largest expansion of the donor
allograft pool in the contemporary era. However, the organ yield and associated costs of …