The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Everyday episodic memories involve linking together related events that are temporally
separated. However, the mechanisms of forming this temporal association have remained …

Acetylcholine release in the central nervous system (CNS) has an important role in attention,
recall, and memory formation. One region influenced by acetylcholine is the hippocampus …

Many of cation-permeable ionotropic receptors to various neurotransmitters, such as
glutamate, acetylcholine and ATP, are permeable to Ca 2+ ions. For some of them, in …

In the hippocampus, activation of nicotinic receptors that include α4 and β2 subunits (α4β2*)
facilitates memory formation. α4β2* receptors may also play a role in nicotine withdrawal …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central nervous
system and play an important role in the control of neural functions including neuronal …

The interest in the action of nicotine in the central nervous system (CNS) has significantly
increased during the past 15 years. This is due in part to the growing importance of nicotine …

Neonicotinoids, which act as agonists of the nicotinic acetylcholine receptors of insects, are
widely used pesticides worldwide. Although epidemiological studies revealed that the …

Background: Aging is a common and inevitable stage in the life cycle of higher organisms.
Different organs, including the central nervous system, are affected by aging in different …