Evolving therapeutic landscape of advanced hepatocellular carcinoma
C Yang, H Zhang, L Zhang, AX Zhu… - Nature reviews …, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
A large proportion of patients with HCC are diagnosed at advanced stages and are only …
[HTML][HTML] Polyphenols as antitumor agents targeting key players in cancer-driving signaling pathways
MH Cháirez-Ramírez, KG de la Cruz-López… - Frontiers in …, 2021 - frontiersin.org
Polyphenols constitute an important group of natural products that are traditionally
associated with a wide range of bioactivities. These are usually found in low concentrations …
associated with a wide range of bioactivities. These are usually found in low concentrations …
[PDF][PDF] Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma
We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …
[PDF][PDF] The global phosphorylation landscape of SARS-CoV-2 infection
M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
Cancer screening recommendations for individuals with Li-Fraumeni syndrome
Li-Fraumeni syndrome (LFS) is an autosomal dominantly inherited condition caused by
germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor …
germline mutations of the TP53 tumor suppressor gene encoding p53, a transcription factor …
[HTML][HTML] Understanding the molecular genetics of basal cell carcinoma
C Pellegrini, MG Maturo, L Di Nardo… - International journal of …, 2017 - mdpi.com
Basal cell carcinoma (BCC) is the most common human cancer and represents a growing
public health care problem. Several tumor suppressor genes and proto-oncogenes have …
public health care problem. Several tumor suppressor genes and proto-oncogenes have …
[PDF][PDF] Liver cancer initiation requires p53 inhibition by CD44-enhanced growth factor signaling
How fully differentiated cells that experience carcinogenic insults become proliferative
cancer progenitors that acquire multiple initiating mutations is not clear. This question is of …
cancer progenitors that acquire multiple initiating mutations is not clear. This question is of …
[HTML][HTML] Ultraviolet radiation and basal cell carcinoma: an environmental perspective
Y Teng, Y Yu, S Li, Y Huang, D Xu, X Tao… - Frontiers in Public …, 2021 - frontiersin.org
Ultraviolet radiation (UVR) is a known carcinogen participated for the development of skin
cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant …
cancers. Solar UVR exposure, particularly ultraviolet B (UVB), is the mostly significant …
DNA damage response/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated with LMNA (Lamin A/C) mutations
Rationale: Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for
laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in …
laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in …
Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies
Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma
correlated with poor patient survival. There are no curative treatments for GB, and it …
correlated with poor patient survival. There are no curative treatments for GB, and it …