Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
widely sanctioned, there are growing concerns about increases in cannabis use disorder …
The collaborative study on the genetics of alcoholism: Brain function
Alcohol use disorder (AUD) and related health conditions result from a complex interaction
of genetic, neural and environmental factors, with differential impacts across the lifespan …
of genetic, neural and environmental factors, with differential impacts across the lifespan …
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
related problems assessed with a questionnaire, is a leading cause of death and morbidity …
The genetic landscape of substance use disorders
Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …
socioeconomic implications worldwide. Twin and family-based studies have long …
Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome
Background: Genome-wide association studies (GWASs) have identified genetic
susceptibility variants for both leukocyte telomere length (LTL) and lung cancer …
susceptibility variants for both leukocyte telomere length (LTL) and lung cancer …
Rare coding variants in CHRNB2 reduce the likelihood of smoking
VM Rajagopal, K Watanabe, J Mbatchou, A Ayer… - Nature Genetics, 2023 - nature.com
Human genetic studies of smoking behavior have been thus far largely limited to common
variants. Studying rare coding variants has the potential to identify drug targets. We …
variants. Studying rare coding variants has the potential to identify drug targets. We …
An approach to identify gene-environment interactions and reveal new biological insight in complex traits
There is a long-standing debate about the magnitude of the contribution of gene-
environment interactions to phenotypic variations of complex traits owing to the low …
environment interactions to phenotypic variations of complex traits owing to the low …
[HTML][HTML] Tobacco toxins induce osteoporosis through ferroptosis
Z Jing, Y Li, H Zhang, T Chen, J Yu, X Xu, Y Zou… - Redox biology, 2023 - Elsevier
Clinical epidemiological studies have confirmed that tobacco smoking disrupts bone
homeostasis and is an independent risk factor for the development of osteoporosis. The low …
homeostasis and is an independent risk factor for the development of osteoporosis. The low …
Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk
Background Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but
the complex relationship and the potential pathway are not fully understood. Methods We …
the complex relationship and the potential pathway are not fully understood. Methods We …
Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people
An East Asian–specific variant on aldehyde dehydrogenase 2 (ALDH2 rs671, G> A) is the
major genetic determinant of alcohol consumption. We performed an rs671 genotype …
major genetic determinant of alcohol consumption. We performed an rs671 genotype …