Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

Malaria affected an estimated 216 million people causing 445,000 deaths in 2016. 1 This
reduced burden of disease and death is a result of more than a century of worldwide effort …

Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin
derivative with a partner drug, in the treatment of uncomplicated malaria has largely been …

Cerebral malaria is a life-threatening complication of malaria caused by the parasite
Plasmodium falciparum. The growing problem of drug resistance and the dearth of new …

Objectives: Identify the pathophysiology of P. falciparum infection. Summarize the findings
seen in a patient with P. falciparum malaria. Describe common complications for patients …

All malaria infections are harmful to both the pregnant mother and the developing fetus. One
in ten maternal deaths in malaria endemic countries are estimated to result from …

Summary Salinipostin A (Sal A) is a potent antiplasmodial marine natural product with an
undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its …

Background Current standard interventions are not universally sufficient for malaria
elimination. The effects of community-based house improvement (HI) and larval source …