Cell competition is a cell fitness-sensing mechanism conserved from insects to mammals
that eliminates those cells that, although viable, are less fit than their neighbors. An …

When fast-growing cells are confronted with slow-growing cells in a mosaic tissue, the slow-
growing cells are often progressively eliminated by apoptosis through a process known as …

Cell competition is a quality control mechanism that eliminates unfit cells. How cells compete
is poorly understood, but it is generally accepted that molecular exchange between cells …

Tumor-host interactions play an increasingly recognized role in modulating tumor growth.
Thus, understanding the nature and impact of this complex bidirectional communication is …

Cell competition acts as a quality-control mechanism that eliminates cells less fit than their
neighbors to optimize organ development. Whether and how competitive interactions occur …

Current theories attribute aging to a failure of selection, due to either pleiotropic constraints
or declining strength of selection after the onset of reproduction. These theories implicitly …

Common cancer theories hold that tumor is an uncontrolled somatic cell proliferation caused
by the progressive addition of random mutations in critical genes that control cell growth …

Adult stem cells reside in local microenvironments (niches) that produce signals regulating
the outcome of stem cell divisions and stem cell–niche interactions. Limited space and …

Throughout their lifetime, cells may suffer insults that reduce their fitness and disrupt their
function, and it is unclear how these potentially harmful cells are managed in adult tissues …

While it is a relatively rare disease, glioblastoma multiform (GBM) is one of the more deadly
adult cancers. Following current interventions, the tumor is never eliminated whatever the …