[HTML][HTML] Immunological approaches to HIV cure
Combination antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV)
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
infection has proven remarkably successful–for those who can access and afford it–yet HIV …
[HTML][HTML] Knowledge from London and Berlin: finding threads to a functional HIV cure
J Ding, Y Liu, Y Lai - Frontiers in Immunology, 2021 - frontiersin.org
Despite the ability of combination antiretroviral therapy (cART) to increase the life
expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs …
expectancy of patients infected with human immunodeficiency virus (HIV), viral reservoirs …
[HTML][HTML] Exosome-mediated stable epigenetic repression of HIV-1
S Shrivastava, RM Ray, L Holguin, L Echavarria… - Nature …, 2021 - nature.com
Abstract Human Immunodeficiency Virus (HIV-1) produces a persistent latent infection.
Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life …
Control of HIV-1 using combination antiretroviral therapy (cART) comes at the cost of life …
[HTML][HTML] SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells
EM Stevenson, S Terry, D Copertino, L Leyre… - Nature …, 2022 - nature.com
Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by
CD8+ cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …
CD8+ cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral …
[HTML][HTML] HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy
EM Stevenson, AR Ward, R Truong, AS Thomas… - JCI insight, 2021 - ncbi.nlm.nih.gov
Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-
lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is …
lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is …
[HTML][HTML] Filgotinib suppresses HIV-1–driven gene transcription by inhibiting HIV-1 splicing and T cell activation
Despite effective antiretroviral therapy, HIV-1–infected cells continue to produce viral
antigens and induce chronic immune exhaustion. We propose to identify HIV-1–suppressing …
antigens and induce chronic immune exhaustion. We propose to identify HIV-1–suppressing …
[HTML][HTML] The splice of life: does RNA processing have a role in HIV-1 persistence?
AO Pasternak, B Berkhout - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus.
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main …
Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main …
[HTML][HTML] Impact of IL-15 and latency reversing agent combinations in the reactivation and NK cell-mediated suppression of the HIV reservoir
DA Covino, MG Desimio, M Doria - Scientific Reports, 2022 - nature.com
Inhibitors of histone deacetylases (HDACis) are major latency reversing agent (LRA)
candidates in 'shock and kill'strategies to eradicate the HIV reservoir in infected patients. The …
candidates in 'shock and kill'strategies to eradicate the HIV reservoir in infected patients. The …
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo
A Gramatica, R Schwarzer, W Brantley… - Journal of …, 2021 - Am Soc Microbiol
An ability to activate latent human immunodeficiency virus type 1 (HIV-1) expression could
benefit many HIV cure strategies; however, most latency-reversing agents (LRAs) have …
benefit many HIV cure strategies; however, most latency-reversing agents (LRAs) have …
The combination of venetoclax and ixazomib selectively and efficiently kills HIV-infected cell lines but has unacceptable toxicity in primary cell models
A Alto, S Natesampillai, AP Chandrasekar… - Journal of …, 2021 - Am Soc Microbiol
The antiapoptotic protein BCL2 inhibits death of HIV-infected cells. Previously, we showed
that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces …
that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces …