The evolving role of tissue-resident memory T cells in infections and cancer
S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …
tissues. TRM form an integral part of the immune sensing network and have the ability to …
[HTML][HTML] The precursors of CD8+ tissue resident memory T cells: from lymphoid organs to infected tissues
L Kok, D Masopust, TN Schumacher - Nature Reviews Immunology, 2022 - nature.com
CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …
Skin barrier immunity and ageing
ES Chambers, M Vukmanovic‐Stejic - Immunology, 2020 - Wiley Online Library
The skin is the outermost layer of the body with an extensive surface area of approximately
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …
1· 8 m2, and is the first line of defence against a multitude of external pathogens and …
Organoids in immunological research
YE Bar-Ephraim, K Kretzschmar… - Nature Reviews …, 2020 - nature.com
Much of our knowledge regarding the interactions between epithelial tissues and the
immune system has been gathered from animal models and co-cultures with cell lines …
immune system has been gathered from animal models and co-cultures with cell lines …
[HTML][HTML] Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
B Virassamy, F Caramia, P Savas, S Sant, J Wang… - Cancer Cell, 2023 - cell.com
CD8+ tumor-infiltrating lymphocytes with a tissue-resident memory T (T RM) cell phenotype
are associated with favorable prognosis in patients with triple-negative breast cancer …
are associated with favorable prognosis in patients with triple-negative breast cancer …
[HTML][HTML] Understanding subset diversity in T cell memory
SC Jameson, D Masopust - Immunity, 2018 - cell.com
Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …
Runx3 drives a CD8+ T cell tissue residency program that is absent in CD4+ T cells
Tissue-resident memory T cells (TRM cells) provide rapid and superior control of localized
infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue …
infections. While the transcription factor Runx3 is a critical regulator of CD8+ T cell tissue …
Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin
The immune system can suppress tumour development both by eliminating malignant cells
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …
and by preventing the outgrowth and spread of cancer cells that resist eradication. Clinical …
Tissue-resident memory T cells: local specialists in immune defence
SN Mueller, LK Mackay - Nature Reviews Immunology, 2016 - nature.com
T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …
of memory T cells around the body is integral to their capacity to provide immune protection …
Tissue-resident T cells and other resident leukocytes
D Masopust, AG Soerens - Annual review of immunology, 2019 - annualreviews.org
Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …
venous blood. Trm cells are heterogeneous but collectively constitute the most abundant …