For many centuries, seeds of Nigella sativa (black cumin), a dicotyledon of the
Ranunculaceae family, have been used as a seasoning spice and food additive in the …

Anti-cancer drugs such as vincristine, paclitaxel, oxaliplatin, cisplatin and bortezomib are
well reported to exert direct and indirect effects on sensory nerves to alter the amplitude of …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

Menstruation has many of the features of an inflammatory process. The complexity and
sequence of inflammatory-type events leading to the final tissue breakdown and bleeding …

There is a brief introductory summary of purinergic signaling involving ATP storage, release,
and ectoenzymatic breakdown, and the current classification of receptor subtypes for …

Spinal cord injury (SCI) triggers inflammation with activation of innate immune responses
that contribute to secondary injury including oligodendrocyte apoptosis, demyelination …

The role of microglia and their contribution to the development and maintenance of pain
states has emerged as an attractive field of study. Sensitization of central nociceptors and …

Abstract Glucomoringin (4 (α-L-rhamnosyloxy)-benzyl glucosinolate)(GMG) is an uncommon
member of glucosinolate group belonging to the Moringaceae family, of which Moringa …

Neuropathic pain after spinal cord injury (SCI) is common, often intractable, and can be
severely debilitating. A number of mechanisms have been proposed for this pain, which are …

This report characterizes the neurobiology of the ocular surface and highlights relevant
mechanisms that may underpin contact lens–related discomfort. While there is limited …