[HTML][HTML] Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging

A Kurioka, P Klenerman - Seminars in Immunology, 2023 - Elsevier
Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and
Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T …

A whole‐course‐repair system based on neurogenesis‐angiogenesis crosstalk and macrophage reprogramming promotes diabetic wound healing

Y Xiong, Z Lin, P Bu, T Yu, Y Endo, W Zhou… - Advanced …, 2023 - Wiley Online Library
Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to
enhance neurogenesis and angiogenesis have appeared to be a promising direction …

MR1 antigen presentation to MAIT cells and other MR1-restricted T cells

HEG McWilliam, JA Villadangos - Nature Reviews Immunology, 2024 - nature.com
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …

Multimodal profiling reveals site-specific adaptation and tissue residency hallmarks of γδ T cells across organs in mice

A Du Halgouet, K Bruder, N Peltokangas… - Nature …, 2024 - nature.com
Abstract γδ T cells perform heterogeneous functions in homeostasis and disease across
tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a …

A conserved transcriptional program for MAIT cells across mammalian evolution

H Bugaut, Y El Morr, M Mestdagh, A Darbois… - Journal of Experimental …, 2023 - rupress.org
Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs,
suggesting important functions. As human and mouse MAIT functional programs appear …

Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease

AC Gnirck, MS Philipp, A Waterhölter… - Nature …, 2023 - nature.com
Mucosal-associated invariant T (MAIT) cells have been implicated in various inflammatory
diseases of barrier organs, but so far, their role in kidney disease is unclear. Here we report …

[HTML][HTML] Role of MAIT cells in gastrointestinal tract bacterial infections in humans: More than a gut feeling

Y Zheng, F Han, A Ho, Y Xue, Z Wu, X Chen… - Mucosal …, 2023 - Elsevier
Mucosa-associated invariant T (MAIT) cells are the largest population of unconventional T
cells in humans. These antimicrobial T cells are poised with rapid effector responses …

The MR1/MAIT cell axis in CNS diseases

R Shrinivasan, SK Wyatt-Johnson… - Brain, Behavior, and …, 2023 - Elsevier
Mucosal-associated invariant T (MAIT) cells are a subpopulation of innate-like T cells that
can be found throughout the body, predominantly in mucosal sites, the lungs and in the …

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis

Y El Morr, M Fürstenheim, M Mestdagh… - Science …, 2024 - science.org
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors
and responds to such changes remains unclear. Here, we describe a protective mechanism …

The emerging role of MAIT cell responses in viral infections

JK Sandberg, E Leeansyah, MA Eller… - The Journal of …, 2023 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like
antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I–related protein 1) …