Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Immune modulation by curcumin: The role of interleukin-10

H Mollazadeh, AFG Cicero, CN Blesso… - Critical reviews in …, 2019 - Taylor & Francis
Cytokines are small secreted proteins released by different types of cells with specific effects
on cellular signaling and communication via binding to their receptors on the cell surface. IL …

Inflammation resolution: implications for atherosclerosis

AC Doran - Circulation research, 2022 - Am Heart Assoc
Resolution is an active and highly coordinated process that occurs in response to
inflammation to limit tissue damage and promote repair. When the resolution program fails …

Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis

M Gao, M Tang, W Ho, Y Teng, Q Chen, L Bu, X Xu… - ACS …, 2023 - ACS Publications
Atherosclerosis is a common pathology present in many cardiovascular diseases. Although
the current therapies (including statins and inhibitors of the serine protease PCSK9) can …

[HTML][HTML] Effect of berberine on atherosclerosis and gut microbiota modulation and their correlation in high-fat diet-fed ApoE−/− mice

M Wu, S Yang, S Wang, Y Cao, R Zhao, X Li… - Frontiers in …, 2020 - frontiersin.org
Atherosclerosis and its associated cardiovascular diseases (CVDs) are serious threats to
human health and have been reported to be associated with the gut microbiota. Recently …

Macrophages in vascular inflammation and atherosclerosis

C Cochain, A Zernecke - Pflügers Archiv-European Journal of Physiology, 2017 - Springer
Atherosclerosis is characterized by lipid accumulation and chronic inflammation of the
arterial wall, and its main complications—myocardial infarction and ischemic stroke …

Sex differences in inflammation during atherosclerosis

DL Fairweather - Clinical Medicine Insights: Cardiology, 2014 - journals.sagepub.com
Atherosclerosis is the leading cause of death in the United States and worldwide, yet more
men die from atherosclerosis than women, and at a younger age. Women, on the other …

Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular disease

L Woodward, I Akoumianakis… - British journal of …, 2017 - Wiley Online Library
Adipose tissue (AT) has recently been identified as a dynamic endocrine organ secreting a
wide range of adipokines. Adiponectin is one such hormone, exerting endocrine and …

Atherosclerosis: orchestrating cells and biomolecules involved in its activation and inhibition

A Munjal, R Khandia - Advances in protein chemistry and structural biology, 2020 - Elsevier
The term atherosclerosis refers to the condition of deposition of lipids and other substances
in and on the artery walls, called as plaque that restricts the normal blood flow. The plaque …

[HTML][HTML] Modified lipoproteins induce arterial wall inflammation during atherogenesis

MB Lorey, K Öörni, PT Kovanen - Frontiers in cardiovascular …, 2022 - frontiersin.org
Circulating apolipoprotein B-containing lipoproteins, notably the low-density lipoproteins,
enter the inner layer of the arterial wall, the intima, where a fraction of them is retained and …