Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

[HTML][HTML] Oxidative stress and bronchopulmonary dysplasia

J Wang, W Dong - Gene, 2018 - Elsevier
With the progress of modern medicine, oxygen therapy has become a crucial measure for
the treatment of premature infants. As an environmental stimulus, in the normal development …

The role of sphingolipid signaling in oxidative lung injury and pathogenesis of bronchopulmonary dysplasia

JM Thomas, T Sudhadevi, P Basa, AW Ha… - International journal of …, 2022 - mdpi.com
Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Resveratrol alleviates alveolar epithelial cell injury induced by hyperoxia by reducing apoptosis and mitochondrial dysfunction

X Zhu, F Wang, X Lei, W Dong - Experimental Biology and …, 2021 - journals.sagepub.com
Bronchopulmonary dysplasia is a severe and long-term pulmonary disease in premature
infants. Hyperoxia-induced acute lung injury plays a critical role in bronchopulmonary …

Changing expression profiles of mRNA, lncRNA, circRNA, and miRNA in lung tissue reveal the pathophysiological of bronchopulmonary dysplasia (BPD) in mouse …

J Wang, J Yin, X Wang, H Liu, Y Hu… - Journal of cellular …, 2019 - Wiley Online Library
New perinatal care technologies have improved the survival rate of preterm neonates, but
the prevalence of bronchopulmonary dysplasia (BPD), one of the most intractable problems …

Protective effects of resveratrol on hyperoxia-induced lung injury in neonatal rats by alleviating apoptosis and ROS production

X Zhu, X Lei, J Wang, W Dong - The Journal of Maternal-Fetal & …, 2020 - Taylor & Francis
Background: Bronchopulmonary dysplasia (BPD) is one of the most common long-term lung
complications of prematurely born infants caused by prolonged injury and repair during …

Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs

AK Shrestha, RT Menon, A El-Saie… - … of Physiology-Lung …, 2020 - journals.physiology.org
Bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH) is a chronic
infantile lung disease that lacks curative therapies. Infants with BPD-associated PH are often …

Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models

R Yang, M Tan, J Xu, X Zhao - … journal of molecular …, 2019 - spandidos-publications.com
The airway epithelium (AE) is the main protective barrier between the host and external
environmental factors causing asthma. Allergens or pathogens induce AE dysfunction …

Genetic deletion of Sphk2 confers protection against Pseudomonas aeruginosa mediated differential expression of genes related to virulent infection and …

DL Ebenezer, P Fu, Y Krishnan, M Maienschein-Cline… - BMC genomics, 2019 - Springer
Background Pseudomonas aeruginosa (PA) is an opportunistic Gram-negative bacterium
that causes serious life threatening and nosocomial infections including pneumonia. PA has …

Advancements in understanding the role of lysophospholipids and their receptors in lung disorders including bronchopulmonary dysplasia

T Sudhadevi, AW Ha, DL Ebenezer, P Fu… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Bronchopulmonary dysplasia (BPD) is a devastating chronic neonatal lung disease leading
to serious adverse consequences. Nearly 15 million babies are born preterm accounting …