Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical Reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Z Zhang, M Kang, H Tan, N Song, M Li, P Xiao… - Chemical Society …, 2022 - pubs.rsc.org
Photo-driven theranostics, also known as phototheranostics, relying on the diverse excited-
state energy conversions of theranostic agents upon photoexcitation represents a significant …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y Xiong, C Xiao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Supramolecular cancer nanotheranostics

J Zhou, L Rao, G Yu, TR Cook, X Chen… - Chemical Society …, 2021 - pubs.rsc.org
Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

Aggregation‐enhanced theranostics: AIE sparkles in biomedical field

M Kang, Z Zhang, N Song, M Li, P Sun, X Chen… - …, 2020 - Wiley Online Library
Theranostics referring to the ingenious integration of diagnostics and therapeutics has
garnered tremendous attention in these years as it provides a promising opportunity for …

Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic‐synergized multimodal therapy

Y Zhou, S Fan, L Feng, X Huang, X Chen - Advanced Materials, 2021 - Wiley Online Library
Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral
Fenton reaction for generating highly toxic hydroxyl free radicals (• OH) to achieve selective …

Glutathione-depleting nanomedicines for synergistic cancer therapy

X Cheng, HD Xu, HH Ran, G Liang, FG Wu - ACS nano, 2021 - ACS Publications
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which
inevitably affects the drugs' therapeutic outcomes. Overexpression of glutathione (GSH) has …

Recent progress of chemodynamic therapy-induced combination cancer therapy

X Wang, X Zhong, Z Liu, L Cheng - Nano Today, 2020 - Elsevier
Chemodynamic therapy (CDT) is an emerging cancer treatment strategy that uses CDT
agents to convert hydrogen peroxide (H 2 O 2) into the hydroxyl radical (radical dotOH), the …

Layered double hydroxide-based nanomaterials for biomedical applications

T Hu, Z Gu, GR Williams, M Strimaite, J Zha… - Chemical Society …, 2022 - pubs.rsc.org
Against the backdrop of increased public health awareness, inorganic nanomaterials have
been widely explored as promising nanoagents for various kinds of biomedical applications …