Sepsis-associated encephalopathy (SAE) is a cognitive impairment associated with sepsis
that occurs in the absence of direct infection in the central nervous system or structural brain …

The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

The treatment of sepsis and septic shock remains a major public health issue due to the
associated morbidity and mortality. Despite an improvement in the understanding of the …

Seizures are a common presenting symptom during viral infections of the central nervous
system (CNS) and can occur during the initial phase of infection (“early” or acute …

This study aimed to explore the protective roles of malvidin in life-threatened sepsis-
associated encephalopathy (SAE) and illustrate the underlying mechanism. SAE mice …

Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive
disease, and even in the immune system. Male sex has been associated with increased …

Background Neuroinflammation mediated by microglial pyroptosis is an important
pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 is …

The blood-brain barrier (BBB) is located at the interface between the vascular system and
the brain parenchyma, and is responsible for communication with systemic circulation and …

Puerarin (Pue), an isoflavone compound extracted from Pueraria, has been shown to inhibit
inflammation and reduce cerebral edema. The neuroprotective effect of puerarin has …

Objective This study aimed to investigate the blood serum levels of biomarkers specifying
oxidative stress status and systemic inflammation between people using methamphetamine …