The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Acute as well as chronic disorders of the nervous system lead to significant morbidity and
mortality for millions of individuals globally. Given the ability to govern stem cell proliferation …

During the last three decades, recombinant DNA technology has produced a wide range of
hematopoietic and neurotrophic growth factors, including erythropoietin (EPO), which has …

Background Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein
deacetylases involved in the regulation of key cancer-associated genes. In this study we …

Mammalian forkhead transcription factors of the O class (FoxO) are exciting targets under
consideration for the development of new clinical entities to treat metabolic disorders and …

Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through
working on different substrate proteins, they display many biological functions, including …

Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in
significant morbidity and mortality. Of further concern is the growing population of individuals …

Sirtuins are NAD-dependent class III histone deacetylase, which modulate the epigenetic
changes to influence the functions in normal and diseased conditions. Preclinical studies …

As a result of the advancing age of the global population and the progressive increase in
lifespan, neurodegenerative disorders continue to increase in incidence throughout the …

Background Breast cancer is usually associated with metastatic features, poor prognosis,
and high mortality. The epithelial-mesenchymal transition (EMT) process has been …