Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Background Janus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and
are effective disease-modifying treatments for several autoimmune diseases. Whether …

Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …

Currently, no oral medications are available for type 1 diabetes (T1D). While our recent
randomized placebo-controlled T1D trial revealed that oral verapamil had short-term …

Previous results indicate the presence of an interferon (IFN) signature in type 1 diabetes
(T1D), capable of inducing chronic inflammation and compromising b cell function. Here, we …

We review the current knowledge of pancreas pathology in type 1 diabetes. During the last
two decades, dedicated efforts toward the recovery of pancreas from deceased patients with …

Autoimmune diseases are typically studied with a focus on the immune system, and less
attention is paid to responses of target tissues exposed to the immune assault. We presently …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of
insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which …

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-
producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is …