The four-membered oxetane ring has been increasingly exploited for its contrasting
behaviors: its influence on physicochemical properties as a stable motif in medicinal …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …

All biological information, since the last common ancestor of all life on Earth, has been
encoded by a genetic alphabet consisting of only four nucleotides that form two base pairs …

Two new C-nucleoside analogues, BCX4430, an imino-C-nucleoside, and GS-6620, a
phosphoramidate derivative of 1′-cyano-2′-C-methyl-4-aza-7, 9-dideazaadenosine C …

Nucleoside analogs are commonly used in the treatment of cancer and viral infections. Their
syntheses benefit from decades of research but are often protracted, unamenable to …

Over the last twenty years, fluorination on nucleoside has established itself as the most
promising tool to use to get biologically active compounds that could sustain the clinical trial …

Canonical nucleosides are vulnerable to enzymatic and chemical degradation, yet their
stable mimics—C‐aryl nucleosides—have demonstrated potential utility in medicinal …

Deazapurine (pyrrolo [2, 3‐d] pyrimidine) nucleosides are important analogues of biogenic
purine nucleosides with diverse biological activities. Replacement of the N7 atom with a …

Glycobiology is the comprehensive biological investigation of carbohydrates. The study of
the role and function of complex carbohydrates often requires the attachment of …