Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: A review

BL Ayilya, A Balde, M Ramya, S Benjakul… - International …, 2023 - Elsevier
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …

Luteolin inhibits herpes simplex virus 1 infection by activating cyclic guanosine monophosphate-adenosine monophosphate synthase-mediated antiviral innate …

Y Wang, F Li, Z Wang, X Song, Z Ren, X Wang, Y Wang… - Phytomedicine, 2023 - Elsevier
Background The successive outbreaks of large-scale infectious diseases due to virus
infection have been a major threat to human health in recent decades. Herpes simplex virus …

GGA (geranylgeranylacetone) ameliorates bleomycin-induced lung inflammation and pulmonary fibrosis by inhibiting apoptosis and oxidative stress

R Zhou, C Jin, L Jiao, S Zhang, M Tian, J Liu… - Molecular Biology …, 2023 - Springer
Background Fibrosis is a response to ongoing cellular injury, disruption, and tissue
remodeling, the pathogenesis of which is unknown, and is characterized by extracellular …

[HTML][HTML] QFAE-nB alleviates pulmonary fibrosis by inhibiting the STING pathway in mice

X Wei, J Jing, R Huang, T Zhou, L Wu, G Ou… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Pulmonary fibrosis (PF) is an irreversible lung disease that
severely affects human respiratory function. Traditionally, the natural plant Quzhou Fructus …

[HTML][HTML] Venlafaxine, an anti-depressant drug, induces apoptosis in MV3 human melanoma cells through JNK1/2-Nur77 signaling pathway

T Niu, Z Wei, J Fu, S Chen, R Wang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Venlafaxine is one of the most commonly used anti-depressant and antineoplastic drug.
Previous studies have predicted venlafaxine as an anti-cancer compound, but the …

[HTML][HTML] Atractylodin ameliorates bleomycin-induced pulmonary inflammation and fibrosis in mice

Z Wu, J Fu, S Zhang, Y Huang, J Xu, M Zhu… - Pharmacological …, 2023 - Elsevier
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease. The
commonly used drugs for the treatment of pulmonary fibrosis can only delay the damage of …

Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs

KMJ Gao, K Chiang, FT Korkmaz, HP Janardhan… - bioRxiv, 2023 - biorxiv.org
Patients afflicted with STING gain-of-function mutations frequently present with debilitating
interstitial lung disease (ILD) that is recapitulated in mice expressing the STINGV154M …

Advances in immunomodulatory mechanisms of mesenchymal stem cells-derived exosome on immune cells in scar formation

W Zhao, H Zhang, R Liu, R Cui - International Journal of …, 2023 - Taylor & Francis
Pathological scars are the result of over-repair and excessive tissue proliferation of the skin
injury. It may cause serious dysfunction, resulting in psychological and physiological …

Carvacrol Protects Rats Against Bleomycin-Induced Lung Oxidative Stress, Inflammation, And Fibrosis

H Rajabi Vardanjani, M Pashmforosh… - Inflammation, And … - papers.ssrn.com
The major goal of this study was to see if carvacrol may help with bleomycin (BLM)-induced
lung fibrosis (PF). Sixty-six male Wistar albino rats were assigned into two main groups: 7 …