The ribosome is a major target for clinically used antibiotics, but multidrug resistant
pathogenic bacteria are making our current arsenal of antimicrobials obsolete. Here we …

Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F
subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The …

During stress conditions such as heat shock and antibiotic exposure, ribosomes stall on
messenger RNAs, leading to inhibition of protein synthesis. To remobilize ribosomes …

Lincosamides are naturally occurring antibiotics isolated from Streptomyces sp. Currently,
lincomycin A and its semisynthetic analogue clindamycin are used as clinical drugs. Due to …

Bacterial HflX is a conserved ribosome-binding GTPase involved in splitting ribosomal
complexes accumulated under stress condition. However, the atomic details of its ribosomal …

Ribosome‐associated GTPases are conserved enzymes that participate in ribosome
biogenesis and ribosome function. In bacteria, recent studies have identified HflX as a …

Ribosome-targeting antibiotics comprise over half of antibiotics used in medicine, but our
fundamental knowledge of their binding sites is derived primarily from ribosome structures of …

HflX is known to rescue stalled ribosomes and is implicated in antibiotic resistance in
several bacteria. Here we present several high-resolution cryo-EM structures of …

Zusammenfassung Die Zunahme multiresistenter Bakterien macht die Entwicklung neuer
verbesserter Antibiotika erforderlich. Das Ribosom ist hierfür als ein Ziel einer breiten …

Ribosome-associated GTPases are conserved enzymes that participate in ribosome
biogenesis and ribosome function. In bacteria, recent studies have identified HflX as a …