Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues.

W Croteau, JC Davey, VA Galton… - The Journal of clinical …, 1996 - Am Soc Clin Investig
The deiodination of thyroid hormones in extrathyroidal tissues plays an important role in
modulating thyroid hormone action. The type II deiodinase (DII) converts thyroxine to the …

The deiodinase family: selenoenzymes regulating thyroid hormone availability and action

J Köhrle - Cellular and Molecular Life Sciences CMLS, 2000 - Springer
Thyroid hormones control growth, development, differentiation and metabolism in
vertebrates. Most of the actions of the active thyroid hormone T3 (3, 5, 3′-triiodo-l …

Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone

HM Tu, SW Kim, D Salvatore, T Bartha… - …, 1997 - academic.oup.com
To identify the specific locations of type 2 deiodinase (D2) messenger RNA (mRNA) in the
hypothalamus and pituitary gland and determine its regulation by thyroid hormone, we …

Role of iodine, selenium and other micronutrients in thyroid function and disorders

V Triggiani, E Tafaro, VA Giagulli… - … Metabolic & Immune …, 2009 - ingentaconnect.com
Micronutrients, mostly iodine and selenium, are required for thyroid hormone synthesis and
function. Iodine is an essential component of thyroid hormones and its deficiency is …

The trace element selenium and the thyroid gland

J Köhrle - Biochimie, 1999 - Elsevier
Apart from the essential trace element iodine, which is the central constitutent of thyroid
hormones, a second essential trace element, selenium, is required for appropriate thyroid …

Selenium as a pleiotropic agent for medical discovery and drug delivery

B Guan, R Yan, R Li, X Zhang - International journal of …, 2018 - Taylor & Francis
Selenium as a biologically active element lends much support to health maintenance and
disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In …

An overview of the ongoing insights in selenium research and its role in fish nutrition and fish health

KU Khan, A Zuberi, JBK Fernandes, I Ullah… - Fish physiology and …, 2017 - Springer
In the present review, the ongoing researches about selenium research in fish nutrition have
been comprehensively discussed. Selenium research is getting popularity in fish nutrition as …

Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone

HM Tu, G Legradi, T Bartha, D Salvatore… - …, 1999 - academic.oup.com
Abstract Type 3 iodothyronine deiodinase (D3) is a selenoenzyme that inactivates thyroid
hormone. It is necessary for T3 homeostasis in the central nervous system. D3 activity has …

Selenium and the control of thyroid hormone metabolism

J Köhrle - Thyroid, 2005 - liebertpub.com
Thyroid hormone synthesis, metabolism and action require adequate availability of the
essential trace elements iodine and selenium, which affect homeostasis of thyroid hormone …

[HTML][HTML] Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase

W Croteau, SL Whittemore, MJ Schneider… - Journal of Biological …, 1995 - ASBMB
The type III iodothyronine deiodinase metabolizes the active thyroid hormones thyroxine and
3, 5, 3'-triiodothyronine to inactive compounds. Recently, we have characterized a Xenopus …