Every week, articles disclosing new antifungal leads reported as promising starting points for
optimization projects are published. In many cases, the mechanism that accounts for their …

Furanone, a five-membered heteroaromatic ring containing oxygen atom, is of immense
pharmaceutical importance. Presence of this nucleus in biologically active compounds of …

Captodative alkene 1-acetylvinyl p-nitrobenzenecarboxylate 1a was evaluated for its
reactivity in Lewis acid-catalyzed Michael additions with functionalized benzene rings and …

The intermolecular α-arylation of esters by palladium-catalyzed coupling of aryl bromides
with zinc enolates of esters is reported. Reactions of three different types of zinc enolates …

Two series of 3-(substituted phenyl)-5-alkyl-2, 5-dihydrofuran-2-ones related to a natural
product,(−) incrustoporine, were synthesized and their in vitro antifungal activity evaluated …

3-(Substituted phenyl)-5-acyloxymethyl-2 H, 5 H-furan-2-ones related to the natural product
(−) incrustoporine were synthesized and their in vitro antifungal activity evaluated. The …

The pharmacological effects of carbon to silicon bioisosteric replacements have been widely
explored in drug design and medicinal chemistry. Here, we present a systematic …

A series of 5-alkoxy derivatives of 3, 4-dichloro-5-hydroxyfuran-2-(5H)-one (mucochloric
acid, MCA) were obtained and subsequently subjected to modification in the C-4 position of …

The last two decades are characterized by major increases in the incidence of systemic
fungal infections caused by the yeast Candida albicans, particularly in immunocompromised …

Six γ-oxa-ε-lactones, 4-phenyl-3, 4-dihydro-2 H-1, 5-benzodioxepin-2-one (5a) and its five
derivatives with methoxy groups in different positions of A and B rings (5b–f), were …