Chronic migraine has a great detrimental influence on a patient's life, with a severe impact
on socioeconomic functioning and quality of life. Chronic migraine affects 1–2% of the …

Migraine is a disabling neurological condition manifesting with attacks of headache,
hypersensitivities to visual, auditory, olfactory and somatosensory stimuli, nausea, and …

Functional imaging using positron emission tomography and later functional magnetic
resonance imaging revealed a particular brainstem area that is believed to be specifically …

Background: Monoclonal antibodies (mAbs) against calcitonin gene-related peptides
(CGRP) are novel treatments for migraine prevention. Based on a previous functional …

Objective: To identify pathophysiologic mechanisms of migraine chronification using a
recently standardized protocol for high-resolution brainstem imaging of trigeminal …

Objective Although migraine is defined by the headache and headache‐associated
symptoms, the true beginning of a migraine attack lies in the premonitory phase. To …

Several lines of evidence suggest a major role of the trigeminovascular system in the
pathogenesis of migraine. Using functional magnetic resonance imaging (fMRI), we …

Functional neuroimaging methods have been used extensively during the last decades to
explore the neural substrates of olfactory processing. While a general consensus on the …

Background The premonitory phase, or prodrome, of migraine, provides valuable
opportunities to study attack initiation and for treating the attack before headache starts …

Objective To determine whether erenumab, a new monoclonal antibody to the calcitonin
gene-related peptide (CGRP) receptor, exerts functional central effects in migraineurs by …