[HTML][HTML] Artificial intelligence in pharmaceutical sciences
Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …
impacts the pharmaceutical market. However, investments in a new drug often go …
[HTML][HTML] Revolutionizing medicinal chemistry: the application of artificial intelligence (AI) in early drug discovery
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical
industry and research, where it has been utilized to efficiently identify new chemical entities …
industry and research, where it has been utilized to efficiently identify new chemical entities …
Genenames. org: the HGNC resources in 2023
RL Seal, B Braschi, K Gray, TEM Jones… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and
names to human genes. The HGNC database (www. genenames. org) currently contains …
names to human genes. The HGNC database (www. genenames. org) currently contains …
The IUPHAR/BPS guide to PHARMACOLOGY in 2024
SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …
guidetopharmacology. org) is an open-access, expert-curated, online database that …
GPCRdb in 2023: state-specific structure models using AlphaFold2 and new ligand resources
G Pándy-Szekeres, J Caroli, A Mamyrbekov… - Nucleic acids …, 2023 - academic.oup.com
G protein-coupled receptors (GPCRs) are physiologically abundant signaling hubs routing
hundreds of extracellular signal substances and drugs into intracellular pathways. The …
hundreds of extracellular signal substances and drugs into intracellular pathways. The …
[HTML][HTML] GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Summary Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …
Pharos 2023: an integrated resource for the understudied human proteome
Abstract The Illuminating the Druggable Genome (IDG) project aims to improve our
understanding of understudied proteins and our ability to study them in the context of …
understanding of understudied proteins and our ability to study them in the context of …
The 2022 Nucleic Acids Research database issue and the online molecular biology database collection
DJ Rigden, XM Fernández - Nucleic acids research, 2022 - academic.oup.com
Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …
87 papers reporting on new databases and 85 updates from resources previously published …
[HTML][HTML] Autoregulation of GPCR signalling through the third intracellular loop
The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
DGIdb 5.0: rebuilding the drug–gene interaction database for precision medicine and drug discovery platforms
Abstract The Drug–Gene Interaction Database (DGIdb, https://dgidb. org) is a publicly
accessible resource that aggregates genes or gene products, drugs and drug–gene …
accessible resource that aggregates genes or gene products, drugs and drug–gene …