Function and therapeutic value of astrocytes in neurological diseases
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …
Roles and regulation of microglia activity in multiple sclerosis: insights from animal models
F Distéfano-Gagné, S Bitarafan, S Lacroix… - Nature Reviews …, 2023 - nature.com
As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …
Spatial proteomics in three-dimensional intact specimens
Spatial molecular profiling of complex tissues is essential to investigate cellular function in
physiological and pathological states. However, methods for molecular analysis of large …
physiological and pathological states. However, methods for molecular analysis of large …
Structural insights into the regulation of human serine palmitoyltransferase complexes
Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-
limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase …
limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase …
The aryl hydrocarbon receptor and the gut–brain axis
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially
identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now …
identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now …
Revisiting the critical roles of reactive astrocytes in neurodegeneration
K Qian, X Jiang, ZQ Liu, J Zhang, P Fu, Y Su… - Molecular …, 2023 - nature.com
Astrocytes, an integral component of the central nervous system (CNS), contribute to the
maintenance of physiological homeostasis through their roles in synaptic function, K+ …
maintenance of physiological homeostasis through their roles in synaptic function, K+ …
Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases
Abstract The Coronavirus Disease 2019 (COVID-19) still tends to propagate and increase
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
Contribution of ceramides metabolism in psychiatric disorders
S Bernal‐Vega, M García‐Juárez… - Journal of …, 2023 - Wiley Online Library
Psychiatric disorders affect 970 million people worldwide, representing a significant source
of disability. Although the underlying neurobiological traits for these disorders are not fully …
of disability. Although the underlying neurobiological traits for these disorders are not fully …
Isotope tracing in health and disease
Highlights•Isotope tracers are used for elucidating substrate utilization, pathway branching,
and metabolic flux rewiring•Recent isotope tracing studies on cancer, neurodegeneration …
and metabolic flux rewiring•Recent isotope tracing studies on cancer, neurodegeneration …
GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice
I Gregorio, L Russo, E Torretta, P Barbacini… - Molecular …, 2024 - Springer
Background Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal
storage Gaucher disease (GD) and are among the most frequent genetic risk factors for …
storage Gaucher disease (GD) and are among the most frequent genetic risk factors for …