Biosynthesis and function of chondroitin sulfate
T Mikami, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2013 - Elsevier
Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …
and extracellular components that form regulatory milieu involving numerous biological and …
Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate
K Sugahara, T Mikami, T Uyama, S Mizuguchi… - Current opinion in …, 2003 - Elsevier
Recent glycobiology studies have suggested fundamental biological functions for
chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as …
chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as …
Formation and remodeling of the brain extracellular matrix in neural plasticity: Roles of chondroitin sulfate and hyaluronan
S Miyata, H Kitagawa - Biochimica et Biophysica Acta (BBA)-General …, 2017 - Elsevier
Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …
A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk
ES Emison, AS McCallion, CS Kashuk, RT Bush… - Nature, 2005 - nature.com
The identification of common variants that contribute to the genesis of human inherited
disorders remains a significant challenge. Hirschsprung disease (HSCR) is a multifactorial …
disorders remains a significant challenge. Hirschsprung disease (HSCR) is a multifactorial …
The GAGOme: a cell-based library of displayed glycosaminoglycans
Glycosaminoglycans (GAGs) are essential polysaccharides in normal physiology and
disease. However, understanding of the contribution of specific GAG structures to specific …
disease. However, understanding of the contribution of specific GAG structures to specific …
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
A progressive loss of cartilage matrix leads to the development of osteoarthritis (OA). Matrix
homeostasis is disturbed in OA cartilage as the result of reduced production of cartilage …
homeostasis is disturbed in OA cartilage as the result of reduced production of cartilage …
Enzymes in the synthesis of glycoconjugates
RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
Interactions between heparan sulfate and proteins—design and functional implications
Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …
animal tissues are essential in development and homeostasis, and variously implicated in …
Mechanisms in protein O-glycan biosynthesis and clinical and molecular aspects of protein O-glycan biosynthesis defects: a review
S Wopereis, DJ Lefeber, E Morava… - Clinical …, 2006 - academic.oup.com
Background: Genetic diseases that affect the biosynthesis of protein O-glycans are a rapidly
growing group of disorders. Because this group of disorders does not have a collective …
growing group of disorders. Because this group of disorders does not have a collective …
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans
S Mizuguchi, T Uyama, H Kitagawa, KH Nomura… - Nature, 2003 - nature.com
Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular
sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes …
sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes …