Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

Recent glycobiology studies have suggested fundamental biological functions for
chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

The identification of common variants that contribute to the genesis of human inherited
disorders remains a significant challenge. Hirschsprung disease (HSCR) is a multifactorial …

Glycosaminoglycans (GAGs) are essential polysaccharides in normal physiology and
disease. However, understanding of the contribution of specific GAG structures to specific …

A progressive loss of cartilage matrix leads to the development of osteoarthritis (OA). Matrix
homeostasis is disturbed in OA cartilage as the result of reduced production of cartilage …

Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Background: Genetic diseases that affect the biosynthesis of protein O-glycans are a rapidly
growing group of disorders. Because this group of disorders does not have a collective …

Glycosaminoglycans such as heparan sulphate and chondroitin sulphate are extracellular
sugar chains involved in intercellular signalling. Disruptions of genes encoding enzymes …