The exercise pressor reflex is a feedback mechanism engaged upon stimulation of mechano-
and metabosensitive skeletal muscle afferents. Activation of these afferents elicits a reflex …

The transient receptor potential (TRP) channel superfamily is a group of non-selective cation
channels functioning as cellular sensors for a wide range of physical, chemical and …

Stimulation of mechanically sensitive channels on the sensory endings of group III and IV
thin fiber muscle afferents activates the mechanoreflex, which contributes to reflex increases …

Electroacupuncture (EA) is considered to have potential antidiabetic effects; however, the
role of the pancreatic intrinsic nervous system (PINS) in EA-induced amelioration of type 2 …

Systemic insulin administration evokes sympathoexcitatory actions, but the mechanisms
underlying these observations are unknown. We reported that insulin sensitizes the …

• The exercise pressor reflex is involved in mediating the altered cardiovascular response to
exercise in T1D and its expression seems to change with disease duration, where an …

Patients with heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF)
exhibit severe exercise intolerance that may be due, in part, to inappropriate cardiovascular …

Introduction: Studies in humans and animals have found that type 2 diabetes mellitus
(T2DM) exaggerates the blood pressure (BP) response to exercise, which increases the risk …

Insulin not only regulates glucose and/or lipid metabolism but also modulates brain neural
activity. The nucleus tractus solitarius (NTS) is a key central integration site for sensory input …

Emerging evidence suggests that type 2 diabetes (T2D) may impair the ability to properly
adjust the circulation during exercise with augmented blood pressure (BP) and an …