Sex differences in inflammation and muscle wasting in aging and disease

C Della Peruta, B Lozanoska-Ochser… - International journal of …, 2023 - mdpi.com
Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Fiber-type traps: revisiting common misconceptions about skeletal muscle fiber types with application to motor control, biomechanics, physiology, and biology

SS Blemker, SV Brooks, KA Esser… - Journal of Applied …, 2024 - journals.physiology.org
Skeletal muscle is a highly complex tissue that is studied by scientists from a wide spectrum
of disciplines, including motor control, biomechanics, exercise science, physiology, cell …

Sex differences in endurance exercise capacity and skeletal muscle lipid metabolism in mice

LE Holcomb, P Rowe, CC O'Neill… - Physiological …, 2022 - Wiley Online Library
Previous studies suggest that sex differences in lipid metabolism exist with females
demonstrating a higher utilization of lipids during exercise, which is mediated partly by …

Skeletal muscle microvascular dysfunction in obesity-related insulin resistance: pathophysiological mechanisms and therapeutic perspectives

CK Ugwoke, E Cvetko, N Umek - International journal of molecular …, 2022 - mdpi.com
Obesity is a worrisomely escalating public health problem globally and one of the leading
causes of morbidity and mortality from noncommunicable disease. The epidemiological link …

Microvascular skeletal-muscle crosstalk in health and disease

GJ Pepe, ED Albrecht - International Journal of Molecular Sciences, 2023 - mdpi.com
As an organ system, skeletal muscle is essential for the generation of energy that underpins
muscle contraction, plays a critical role in controlling energy balance and insulin-dependent …

Muscle miRNAs are influenced by sex at baseline and in response to exercise

D Hiam, S Landen, M Jacques, S Voisin, S Lamon… - BMC biology, 2023 - Springer
Background Sex differences in microRNA (miRNA) expression profiles have been found
across multiple tissues. Skeletal muscle is one of the most sex-biased tissues of the body …

NMJ-related diseases beyond the congenital myasthenic syndromes

A Navarro-Martínez, C Vicente-García… - Frontiers in Cell and …, 2023 - frontiersin.org
Neuromuscular junctions (NMJs) are a special type of chemical synapse that transmits
electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle to induce a …

Advances in Tissue Engineering Approaches for Repairing and Rehabilitating the Myotendinous Junction

KA Shama, MA Turner, HB Broadaway… - Current Opinion in …, 2024 - Elsevier
The myotendinous junction (MTJ) acts as a bridge between muscle and tendon; yet its high
stiffness relative to muscle fibers renders the tissue susceptible to injuries due to eccentric …

Different responses of skeletal muscles to femoral artery ligation-induced ischemia identified in BABL/c and C57BL/6 mice

H Tu, J Qian, D Zhang, AN Barksdale… - Frontiers in …, 2022 - frontiersin.org
Peripheral arterial disease (PAD) is a common circulatory problem in lower extremities, and
the murine ischemic model is used to reproduce human PAD. To compare strain differences …

Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia‐inducible factor‐1α in normoxia

N Welch, S Mishra, A Bellar, P Kannan… - The Journal of …, 2024 - Wiley Online Library
Abstract Hypoxia‐inducible factor (HIF)‐1α is continuously synthesized and degraded in
normoxia. During hypoxia, HIF1α stabilization restricts cellular/mitochondrial oxygen …