Septins are conserved GTP-binding proteins that associate with cellular membranes and the
actin and microtubule cytoskeletons. They polymerize to form filamentous structures that act …

Peterson EA and Petty EM. Conquering the complex world of human septins: implications for
health and disease. Septins are highly conserved filamentous proteins first characterized in …

Abstract Introduction Altered expression of Septin 9 (SEPT9), a septin coding for multiple
isoform variants, has been observed in several carcinomas, including colorectal, head and …

Septins are a family of cytoskeleton related proteins consisting of 14 members that associate
and interact with actin and tubulin. From yeast to humans, septins maintain a conserved role …

Septins, a conserved family of cytoskeletal GTP-binding proteins, were presented in diverse
eukaryotes. Here, a comprehensive phylogenetic and evolutionary analysis for septin …

SEPT9 gene methylation has been implicated as a biomarker for colorectal cancer (CRC) for
more than 10 years and has been used clinically for more than 6 years. Studies have proven …

Background Septins belong to the GTPase superclass of proteins and have been
functionally implicated in cytokinesis and the maintenance of cellular morphology. They are …

For years evolutionary biologists have been interested in searching for the genetic bases
underlying humanness. Recent efforts at a large or a complete genomic scale have been …

Background Septins are conserved GTPases that form filaments and are required in many
organisms for several processes including cytokinesis. We previously identified SEPT9 …

Functions of septin cytoskeletal polymers in tumorigenesis are still poorly defined. Their role
in the regulation of cytokinesis and cell migration were proposed to contribute to cancer …