Septin GTP-binding proteins contribute essential biological functions that range from the
establishment of cell polarity to animal tissue morphogenesis. Human septins in cells form …

The treatment and prognosis of malignant tumors are closely related to the time when the
tumors are diagnosed; the earlier the diagnosis of the tumor, the better the prognosis …

The assembly of a septin filament requires that homologous monomers must distinguish
between one another in establishing appropriate interfaces with their neighbors. To …

Septins constitute a group of GTP binding proteins that assemble into homo-and hetero-
oligomeric complexes and filaments. These higher order septin structures are thought to …

Genetic variations in dysbindin-1 (dystrobrevin-binding protein-1) are one of the most
commonly reported variations associated with schizophrenia. As schizophrenia could be …

Abstract Septin9 (Sept9) is a member of the filament-forming septin family of structural
proteins and is associated with a variety of cancers and with hereditary neuralgic …

Protein-protein interactions play a critical role in promoting the stability of protein quaternary
structure and in the assembly of large macromolecular complexes. What drives the …

Human septins 3, 9 and 12 are the only members of a specific subgroup of septins that
display several unusual features, including the absence of a C-terminal coiled coil. This …

Septins are a conserved family of cytoskeletal GTP ases present in different organisms,
including yeast, drosophila, Caenorhabditis elegans and humans. In humans, septins are …

Mammalian septins comprise a family of 13 genes that encode GTP-binding proteins.
Specific combinations of septins can hetero-oligomerize and form filaments in vivo and in …