Abstract Septin 7 (SEPT7) has been described to be essential for successful completion of
cytokinesis in mouse fibroblasts and Sept7-deficiency in fibroblasts constitutively results in …

Septins form a conserved family of filament forming GTP binding proteins found in a wide
range of eukaryotic cells. They share a common structural architecture consisting of an N …

While the original septin mutants were identified more than 30 years ago for their role in
cytokinesis [Hartwell, LH: Genetic control of the cell division cycle in yeast. IV. Genes …

There is growing evidence for crosstalk between septin filaments and actin cytoskeleton
which is regulated by Rho family of GTPases. Here we show that active Rho disrupts septin …

MicroRNAs (miRNAs) are small non-coding RNAs of 20-25 nucleotides in length that are
capable of modulating gene expression post-transcriptionally. The potential roles of miRNAs …

Septins are evolutionarily conserved GTP-binding proteins that can heteropolymerize into
filaments. Recent studies have revealed that septins are involved in not only diverse normal …

The physical division of one cell into two requires the highly orchestrated separation of
genetic and cytoplasmic contents during M phase of the cell cycle. Mitosis, the physical …

Several lines of evidence indicate that altered expression of SEPT9 is seen in human
neoplasia. In particular there is evidence of altered expression of the SEPT9_v4 isoform …

Septins are filament-forming GTPases implicated in several cellular functions, including
cytokinesis. We previously showed that SEPT2, SEPT9, and SEPT11 colocalize with several …

The septin family of GTPases, first identified for their roles in cell division, are also expressed
in postmitotic tissues. SEPT3 (G-septin) and SEPT5 (CDCrel-1) are highly expressed in …