Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …
second most prevalent aortic disease following atherosclerosis, representing the ninth …
[HTML][HTML] Risk factors for thoracic aortic dissection
Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time
until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic …
until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic …
Design considerations, formulation approaches, and strategic advances of hydrogel dressings for chronic wound management
Wound healing is a complex and dynamic physiological process consisting of a series of
cellular and molecular events that initiate immediately after a tissue lesion, to reconstruct the …
cellular and molecular events that initiate immediately after a tissue lesion, to reconstruct the …
How does hemodynamics affect rupture tissue mechanics in abdominal aortic aneurysm: Focus on wall shear stress derived parameters, time-averaged wall shear …
An abdominal aortic aneurysm (AAA) is a critical health condition with a risk of rupture,
where the diameter of the aorta enlarges more than 50% of its normal diameter. The …
where the diameter of the aorta enlarges more than 50% of its normal diameter. The …
[HTML][HTML] Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study
Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
EACTS/STS Guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ
M Czerny, M Grabenwöger, T Berger… - European Journal of …, 2024 - academic.oup.com
These guidelines, endorsed by both the EACTS and STS, represent the official viewpoint on
this topic. They show a commitment to ongoing improvement, as regular updates will be …
this topic. They show a commitment to ongoing improvement, as regular updates will be …
[HTML][HTML] ER stress mediates Angiotensin II-augmented innate immunity memory and facilitates distinct susceptibilities of thoracic from abdominal aorta to aneurysm …
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from …
Genetics and mechanisms of thoracic aortic disease
Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation
or abnormalities in aortic function, such as loss of aortic distensibility. Genetic analysis in …
or abnormalities in aortic function, such as loss of aortic distensibility. Genetic analysis in …
Aortic cellular diversity and quantitative genome-wide association study trait prioritization through single-nuclear RNA sequencing of the aneurysmal human aorta
EL Chou, M Chaffin, B Simonson… - … and Vascular Biology, 2022 - Am Heart Assoc
Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …
promote extracellular matrix destruction and structural weakening. To explore this biology …
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Aims This study aims to outline the 'true'natural history of ascending thoracic aortic
aneurysm (ATAA) based on a cohort of patients not undergoing surgical intervention …
aneurysm (ATAA) based on a cohort of patients not undergoing surgical intervention …