Awareness and current knowledge of epilepsy
Epilepsy is a severe neural disorder that affects approximately fifty million individuals
globally. Despite the fact that for most of the people with epilepsy, convulsions are better …
globally. Despite the fact that for most of the people with epilepsy, convulsions are better …
N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain
P Medeiros, SE Negrini-Ferrari, E Palazzo… - Neurochemical …, 2019 - Springer
The mechanisms underlying chronic and neuropathic pain pathology involve peripheral and
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception …
M Mendonça-dos-Santos, TCT Gonçalves… - Scientific Reports, 2024 - nature.com
We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …
The role of dorsomedial and ventrolateral columns of the periaqueductal gray matter and in situ 5‐HT2A and 5‐HT2C serotonergic receptors in post‐ictal …
RL de Freitas, RC de Oliveira, R de Oliveira… - Synapse, 2014 - Wiley Online Library
The periaqueductal gray matter (PAG) consists in a brainstem structure rich in 5‐
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …
hydroxytryptamine (5‐HT) inputs related to the modulation of pain. The involvement of each …
The regulation of the pedunculopontine tegmental nucleus in sleep–wake states
Y Luo, Y Li, J Yuan - Sleep and Biological Rhythms, 2024 - Springer
The pedunculopontine tegmental nucleus (PPTg) plays a vital role in sleep/wake states.
There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic …
There are three main kinds of heterogeneous neurons involved: cholinergic, glutamatergic …
D2-like receptor activation by intranasal dopamine attenuates fear responses induced by electrical stimulation of the dorsal periaqueductal grey matter, but fails to …
RM de Figueiredo… - Journal of …, 2022 - journals.sagepub.com
Background: Panic-like reactions elicited by electrical stimulation of the dorsal
periaqueductal grey matter (ES-dPAG) seem to be regulated by dopamine (DA). We showed …
periaqueductal grey matter (ES-dPAG) seem to be regulated by dopamine (DA). We showed …
µ1‐Opioid receptors in the dorsomedial and ventrolateral columns of the periaqueductal grey matter are critical for the enhancement of post‐ictal antinociception
Generalised tonic and tonic–clonic seizures are followed by significant increase in
nociceptive thresholds in both laboratory animals and humans. The endogenous opioid …
nociceptive thresholds in both laboratory animals and humans. The endogenous opioid …
Effect of electrical and chemical (activation versus inactivation) stimulation of the infralimbic division of the medial prefrontal cortex in rats with chronic neuropathic pain
TL Moura-Pacheco, RC Martins-Pereira… - Experimental Brain …, 2023 - Springer
Neuropathic pain (NP) represents a complex disorder with sensory, cognitive, and emotional
symptoms. The medial prefrontal cortex (mPFC) takes critical regulatory roles and may …
symptoms. The medial prefrontal cortex (mPFC) takes critical regulatory roles and may …
The μ1-opioid receptor and 5-HT2A-and 5HT2C-serotonergic receptors of the locus coeruleus are critical in elaborating hypoalgesia induced by tonic and tonic–clonic …
It has been proposed that the post-ictal state is associated with the expression of
hypoalgesia. It is clear that the projections among the periaqueductal gray matter (PAG) …
hypoalgesia. It is clear that the projections among the periaqueductal gray matter (PAG) …
Ictal analgesia in temporal lobe epilepsy–The mechanism of seizure-related burns
A Szűcs, A Horváth, G Rásonyi, D Fabó, G Szabó… - Medical hypotheses, 2015 - Elsevier
Seizure-related injuries have major impact in the excess mortality and morbidity of epilepsy
patients. Experimental data suggest that analgesia may develop during seizures …
patients. Experimental data suggest that analgesia may develop during seizures …