Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to infection. In this context, biomarkers could be considered as indicators of either …

Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

The most recent European guidelines and task force reports on hospital-acquired
pneumonia (HAP) and ventilator-associated pneumonia (VAP) were published almost 10 …

Summary Background In February, 2017, the US Food and Drug Administration approved
the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute …

Background The effect of procalcitonin-guided use of antibiotics on treatment for suspected
lower respiratory tract infection is unclear. Methods In 14 US hospitals with high adherence …

Procalcitonin (PCT) is a protein that consists of 116 amino acids and is the peptide precursor
of calcitonin. Calcitonin is initially biosynthesized as PCT, which, under normal conditions, is …

Background The clinical utility of serum procalcitonin levels in guiding antibiotic treatment
decisions in patients with sepsis remains unclear. This patient-level meta-analysis based on …

Abstract Background Acute respiratory infections (ARIs) comprise a large and
heterogeneous group of infections including bacterial, viral and other aetiologies. In recent …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …