Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multiorgan
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …
[HTML][HTML] Beyond genetics: the role of metabolism in photoreceptor survival, development and repair
J Hanna, LA David, Y Touahri, T Fleming… - Frontiers in cell and …, 2022 - frontiersin.org
Vision commences in the retina with rod and cone photoreceptors that detect and convert
light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative …
light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative …
[HTML][HTML] Omega-3/Omega-6 long-chain fatty acid imbalance in phase I retinopathy of prematurity
There is a gap in understanding the effect of the essential ω-3 and ω-6 long-chain
polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which …
polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which …
[HTML][HTML] Neural and Müller glial adaptation of the retina to photoreceptor degeneration
HO Leinonen, E Bull, Z Fu - Neural Regeneration Research, 2023 - journals.lww.com
The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …
degeneration are characterized by decay of the outer retina and photoreceptors, which …
[HTML][HTML] FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP
Hyperglycemia in early postnatal life of preterm infants with incompletely vascularized
retinas is associated with increased risk of potentially blinding neovascular retinopathy of …
retinas is associated with increased risk of potentially blinding neovascular retinopathy of …
Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice
Introduction Choroidal neovascularization (CNV) in age-related macular degeneration
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
[HTML][HTML] Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration
N Shigesada, N Shikada, M Shirai, M Toriyama… - Cellular and Molecular …, 2024 - Springer
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction,
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …
[HTML][HTML] Retinal gliosis and phenotypic diversity of intermediate filament induction and remodeling upon acoustic blast overpressure (ABO) exposure to the rat eye
Traumatic brain injury (TBI) caused by acoustic blast overpressure (ABO) is frequently
associated with chronic visual deficits in military personnel and civilians. In this study, we …
associated with chronic visual deficits in military personnel and civilians. In this study, we …
[HTML][HTML] Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells
I Barravecchia, C De Cesari, V Guadagni, G Signore… - Scientific Reports, 2023 - nature.com
In proliferating multipotent retinal progenitors, transcription factors dynamics set the fate of
postmitotic daughter cells, but postmitotic cell fate plasticity driven by extrinsic factors …
postmitotic daughter cells, but postmitotic cell fate plasticity driven by extrinsic factors …
TIMP3/Wnt axis regulates gliosis of Müller glia
JH Hung, PH Tsai, FA Wilson Jr, CC Chen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Previous studies have confirmed the expression of tissue inhibitor of
metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains …
metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains …