Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects

HY Chen, M Swaroop, S Papal, AK Mondal, HB Song… - elife, 2023 - elifesciences.org
Ciliopathies manifest from sensory abnormalities to syndromic disorders with multiorgan
pathologies, with retinal degeneration a highly penetrant phenotype. Photoreceptor cell …

[HTML][HTML] Beyond genetics: the role of metabolism in photoreceptor survival, development and repair

J Hanna, LA David, Y Touahri, T Fleming… - Frontiers in cell and …, 2022 - frontiersin.org
Vision commences in the retina with rod and cone photoreceptors that detect and convert
light to electrical signals. The irreversible loss of photoreceptors due to neurodegenerative …

[HTML][HTML] Omega-3/Omega-6 long-chain fatty acid imbalance in phase I retinopathy of prematurity

Z Fu, W Yan, CT Chen, AK Nilsson, E Bull, W Allen… - Nutrients, 2022 - mdpi.com
There is a gap in understanding the effect of the essential ω-3 and ω-6 long-chain
polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which …

[HTML][HTML] Neural and Müller glial adaptation of the retina to photoreceptor degeneration

HO Leinonen, E Bull, Z Fu - Neural Regeneration Research, 2023 - journals.lww.com
The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …

[HTML][HTML] FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP

Z Fu, P Lundgren, A Pivodic, H Yagi, JC Harman… - Angiogenesis, 2023 - Springer
Hyperglycemia in early postnatal life of preterm infants with incompletely vascularized
retinas is associated with increased risk of potentially blinding neovascular retinopathy of …

Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice

Y Gong, Y Tomita, ML Edin, A Ren, M Ko, J Yang… - Metabolism, 2022 - Elsevier
Introduction Choroidal neovascularization (CNV) in age-related macular degeneration
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …

[HTML][HTML] Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration

N Shigesada, N Shikada, M Shirai, M Toriyama… - Cellular and Molecular …, 2024 - Springer
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction,
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …

[HTML][HTML] Retinal gliosis and phenotypic diversity of intermediate filament induction and remodeling upon acoustic blast overpressure (ABO) exposure to the rat eye

LA Skelton, SR Rao, RS Allen, CT Motz… - Experimental eye …, 2023 - Elsevier
Traumatic brain injury (TBI) caused by acoustic blast overpressure (ABO) is frequently
associated with chronic visual deficits in military personnel and civilians. In this study, we …

[HTML][HTML] Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells

I Barravecchia, C De Cesari, V Guadagni, G Signore… - Scientific Reports, 2023 - nature.com
In proliferating multipotent retinal progenitors, transcription factors dynamics set the fate of
postmitotic daughter cells, but postmitotic cell fate plasticity driven by extrinsic factors …

TIMP3/Wnt axis regulates gliosis of Müller glia

JH Hung, PH Tsai, FA Wilson Jr, CC Chen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Previous studies have confirmed the expression of tissue inhibitor of
metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains …