Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …

This paper discusses the promising areas of research into machine learning applications for
the prevention and correction of neurodegenerative and depressive disorders. These two …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

Environmental risks are a substantial factor in the current burden of disease, and their role is
likely to increase in the future. Model-based scenario analysis is used extensively in …

Personality is influenced by both genetic and environmental factors and is associated with
other psychiatric traits such as anxiety and depression. The 'big five'personality traits, which …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting
pain daily or on most days. It adversely affects the quality of life and imposes substantial …

The ketogenic diet (KD, also known as metabolic therapy) has been successful in the
treatment of obesity, type 2 diabetes, and epilepsy. More recently, this treatment has shown …

Health effects of endocrine disrupting chemicals (EDCs) are challenging to detect in the
general population. Omics technologies become increasingly common to identify early …

Gut dysbiosis and psychiatric symptoms are common early manifestations of Alzheimer's
disease (AD) and Parkinson's disease (PD). These diseases, characterised by progressive …