Functional evolution of nuclear structure
The evolution of the nucleus, the defining feature of eukaryotic cells, was long shrouded in
speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) …
speculation and mystery. There is now strong evidence that nuclear pore complexes (NPCs) …
Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis
H Nakano, T Funasaka, C Hashizume… - Journal of Biological …, 2010 - ASBMB
Gain or loss of whole chromosomes is often observed in cancer cells and is thought to be
due to aberrant chromosome segregation during mitosis. Proper chromosome segregation …
due to aberrant chromosome segregation during mitosis. Proper chromosome segregation …
An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region
The mitotic spindle is a microtubular assembly required for chromosome segregation during
mitosis. Additionally, a spindle matrix has long been proposed to assist this process, but its …
mitosis. Additionally, a spindle matrix has long been proposed to assist this process, but its …
Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport
The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling
assembly and disassembly of nuclear transport complexes. RanGTP is required in the …
assembly and disassembly of nuclear transport complexes. RanGTP is required in the …
The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation
The formation of the mitotic spindle is a complex process that requires massive cellular
reorganization. Regulation by mitotic kinases controls this entire process. One of these …
reorganization. Regulation by mitotic kinases controls this entire process. One of these …
Nuclear transport and the mitotic apparatus: an evolving relationship
The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by
the nuclear pore complexes (NPCs) and various transport factors that facilitate the …
the nuclear pore complexes (NPCs) and various transport factors that facilitate the …
Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling
As a sensitive signaling system, the mitotic checkpoint ensures faithful chromosome
segregation by delaying anaphase onset even when a single kinetochore is unattached to …
segregation by delaying anaphase onset even when a single kinetochore is unattached to …
MAD1: kinetochore receptors and catalytic mechanisms
The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase
onset and prevents aneuploidy when unattached or tensionless kinetochores are present in …
onset and prevents aneuploidy when unattached or tensionless kinetochores are present in …
A membranous spindle matrix orchestrates cell division
Y Zheng - Nature reviews Molecular cell biology, 2010 - nature.com
Eukaryotic cell division uses morphologically different forms of mitosis, referred to as open,
partially open and closed mitosis, for accurate chromosome segregation and proper …
partially open and closed mitosis, for accurate chromosome segregation and proper …
Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy
Y Ling, X Zhang, Y Bai, P Li, C Wei, T Song… - Biochemical and …, 2014 - Elsevier
The spindle assembly checkpoint kinase Mps1 is highly expressed in several types of
cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that …
cancers, but its cellular involvement in tumorigenesis is less defined. Herein, we confirm that …