A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

The ultimate origin of Lewy body disorders, including Parkinson's disease (PD) and
Dementia with Lewy bodies (DLB), is still incompletely understood. Although a large number …

The dual-hit hypothesis of Parkinson's disease (PD) originally postulated that a neurotropic
pathogen leads to formation of α-synuclein pathology in the olfactory bulb (OB) and dorsal …

Objective To investigate whether the CSF α-synuclein (α-syn) real-time quaking-induced
conversion (RT-QuIC) assay accurately identifies patients with mild cognitive impairment …

Neurologists nowadays no longer view neurodegenerative diseases, like Parkinson's and
Alzheimer's disease, as single entities, but rather as a spectrum of multifaceted symptoms …

Background: Research criteria for prodromal dementia with Lewy bodies (DLB) were
published in 2020, but little is known regarding prodromal DLB in clinical settings. Methods …

Abstract Background The DEmEntia with LEwy bOdies Project (DEvELOP) aims to
phenotype patients with dementia with Lewy bodies (DLB) and study the symptoms and …

Dementia with Lewy bodies (DLB), the second most common degenerative neurocognitive
disorder after Alzheimer disease (AD), is frequently preceded by a period of mild cognitive …

Differential diagnosis between Parkinson's disease, dementia with Lewy bodies and
multiple system atrophy can be difficult, especially because in early phase they might …

Dementia with Lewy bodies is characterized by a high burden of autonomic dysfunction and
Lewy pathology in peripheral organs and components of the sympathetic and …