Revisiting the Warburg effect: historical dogma versus current understanding

P Vaupel, G Multhoff - The Journal of physiology, 2021 - Wiley Online Library
Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary,
permanent and universal consequence of dysfunctional or impaired mitochondria …

Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation

C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

J Jin, Y Xie, JS Zhang, JQ Wang, SJ Dai, W He… - Drug Resistance …, 2023 - Elsevier
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer

B Xie, J Lin, X Chen, X Zhou, Y Zhang, M Fan, J Xiang… - Molecular Cancer, 2023 - Springer
Abstract Background Bladder cancer (BCa) is the fourth most common malignant tumor with
a poor prognosis worldwide. Further exploration and research are needed to unmask the …

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

F Danzi, R Pacchiana, A Mafficini, MT Scupoli… - … and Targeted Therapy, 2023 - nature.com
Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma

W Gong, J Xu, Y Wang, Q Min, X Chen… - … and Targeted Therapy, 2022 - nature.com
Circular RNAs (circRNAs) were shown to play an important role in the occurrence and
progression of tumors. However, the functions of nuclear genome-derived circRNAs …

A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity

Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …

Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes

M Coluccia, V Parisse, P Guglielmi, G Giannini… - European Journal of …, 2022 - Elsevier
Metal-organic frameworks (MOF) have been studied for infinite applications. Among these,
anticancer therapy has surely attracted great interest due to the intrinsic characteristics of …