Revisiting the Warburg effect: historical dogma versus current understanding
P Vaupel, G Multhoff - The Journal of physiology, 2021 - Wiley Online Library
Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary,
permanent and universal consequence of dysfunctional or impaired mitochondria …
permanent and universal consequence of dysfunctional or impaired mitochondria …
Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation
C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …
and proliferation. These metabolic alterations include (1) a shift from oxidative …
In response to precision medicine: Current subcellular targeting strategies for cancer therapy
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …
increasing attention, bringing great opportunities for clinical application. Here, two targeting …
The potential of metabolomics in biomedical applications
V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …
Current high-throughput technologies have allowed the discovery of relevant metabolites …
[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers
Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …
CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer
B Xie, J Lin, X Chen, X Zhou, Y Zhang, M Fan, J Xiang… - Molecular Cancer, 2023 - Springer
Abstract Background Bladder cancer (BCa) is the fourth most common malignant tumor with
a poor prognosis worldwide. Further exploration and research are needed to unmask the …
a poor prognosis worldwide. Further exploration and research are needed to unmask the …
To metabolomics and beyond: a technological portfolio to investigate cancer metabolism
F Danzi, R Pacchiana, A Mafficini, MT Scupoli… - … and Targeted Therapy, 2023 - nature.com
Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …
Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma
W Gong, J Xu, Y Wang, Q Min, X Chen… - … and Targeted Therapy, 2022 - nature.com
Circular RNAs (circRNAs) were shown to play an important role in the occurrence and
progression of tumors. However, the functions of nuclear genome-derived circRNAs …
progression of tumors. However, the functions of nuclear genome-derived circRNAs …
A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity
Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …
Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes
M Coluccia, V Parisse, P Guglielmi, G Giannini… - European Journal of …, 2022 - Elsevier
Metal-organic frameworks (MOF) have been studied for infinite applications. Among these,
anticancer therapy has surely attracted great interest due to the intrinsic characteristics of …
anticancer therapy has surely attracted great interest due to the intrinsic characteristics of …