The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Cell death is an essential immunological apparatus of host defense, but dysregulation of
mutually inclusive cell deaths poses severe threats during microbial and parasitic infections …

Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …

The nucleotide-binding domain and leucine-rich-repeat-containing family
(NLRs)(sometimes called the NOD-like receptors, though the family contains few bona fide …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

Pancreatic cancer is a deadly malignancy with limited treatment options. NLRX1 is a unique,
understudied member of the Nod-like Receptor (NLR) family of pattern recognition receptors …

Simple Summary The pathogenesis of intestinal inflammatory disorders such as colitis and
colorectal cancer is complicated and dysregulation of gut microbiota is considered an …

Inflammasomes, composed of the nucleotide-binding oligomerization domain (NOD)-like
receptors (NLRs), are immune-functional protein multimers that are closely linked to the host …

The pathogeneses of psoriasis and metabolic syndrome are closely related; however, the
underlying biological mechanisms are yet to be clarified. A psoriasis training set was …