Crohn's disease (CD) and ulcerative colitis (UC), known as inflammatory bowel disease
(IBD), are fairly common chronic inflammatory conditions of the gastrointestinal tract …

Virtually all inflammatory mediators investigated to date seem to be dysregulated in the
inflamed intestinal mucosa of patients with inflammatory bowel disease. However, which of …

Mucosal antibody defense depends on a complex cooperation between local B cells and
secretory epithelia. Mucosa‐associated lymphoid tissue gives rise to B cells with striking J …

Mucosal surfaces are protected specifically by secretory immunoglobulin A (SIgA) and SIgM
generated through external translocation of locally produced dimeric IgA and pentameric …

Animal models of inflammatory bowel disease (IBD) have been useful in the identification of
those immune responses uniquely involved in IBD pathogenesis and in defining the …

Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by
anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing …

Background: Intestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC) is
characterised by an influx of neutrophils into the intestinal mucosa. S100A12 is a calcium …

The gastrointestinal (GI) tract is crucial for food digestion and nutrient absorption in humans.
However, the GI tract is usually challenged with oxidative stress that can be induced by …

The mucosae and exocrine glands harbour the largest activated B‐cell system of the body,
amounting to some 80–90% of all immunoglobulins (Ig)‐producing cells. The major product …

Inflammatory bowel disease is a chronic intestinal inflammatory condition, the pathology of
which is incompletely understood. Gut inflammation causes significant changes in neurally …