The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate
protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of …

Cyclic AMP is a ubiquitous intracellular second messenger involved in the regulation of a
wide variety of cellular processes, a majority of which act through the cAMP–protein kinase …

To explore the possibility of constrained peptides to target Plasmodium-infected cells, we
designed a J domain mimetic derived from Plasmodium falciparum calcium-dependent …

Anomalous protein-protein interactions (PPIs) have been correlated to a variety of disease
states, such as cancer, infectious disease, neurological disorders, diabetes, endocrine …

Malaria remains an endemic tropical disease, and the emergence of Plasmodium falciparum
parasites resistant to current front-line medicines means that new therapeutic targets are …

The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-
threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such …

Malaria remains a worldwide health concern with an estimated quarter of a billion people
infected and nearly half a million deaths annually. Malaria is caused by a parasite infection …

Abstract The 3′–5′-cyclic adenosine monophosphate (cAMP)/PKA pathway represents a
major target for pharmacological intervention in multiple disease conditions. Although the …

We review the role of signaling pathways in regulation of the key processes of merozoite
egress and red blood cell invasion by Plasmodium falciparum and, in particular, the …

Malaria is one of the most impacting public health problems in tropical and subtropical areas
of the globe, with approximately 200 million cases worldwide annually. In the absence of an …