This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Proximity biotinylation workflows typically require CRISPR-based genetic manipulation of
target cells. To overcome this bottleneck, we fused the TurboID proximity biotinylation …

Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin
regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear …

Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

The genome of a eukaryotic organism is comprised of a supra-molecular complex of
chromatin fibers and intricately folded three-dimensional (3D) structures. Chromosomal …

Nuclear lamins are type‐V intermediate filaments that are involved in many nuclear
processes. In mammals, A‐and B‐type lamins assemble into separate physical meshwork …

Background The dynamic 3D organization of the genome is central to gene regulation and
development. The nuclear lamina influences genome organization through the tethering of …

Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear
periphery. These domains have been implicated in gene repression, especially in the …

The nuclear lamina serves important functions in the nucleus, providing structural support to
the nuclear envelope and contributing to chromatin organization. The primary proteins that …