Role of epithelial sodium channel-related inflammation in human diseases

Y Chen, X Yu, Z Yan, S Zhang, J Zhang… - Frontiers in …, 2023 - frontiersin.org
The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …

Corin: a key mediator in sodium homeostasis, vascular remodeling, and heart failure

X Zhang, X Gu, Y Zhang, N Dong, Q Wu - Biology, 2022 - mdpi.com
Simple Summary Atrial natriuretic peptide (ANP) is an important hormone that regulates
many physiological and pathological processes, including electrolyte and body fluid …

Type II transmembrane serine proteases as modulators in adipose tissue phenotype and function

Q Wu, S Li, X Zhang, N Dong - Biomedicines, 2023 - mdpi.com
Adipose tissue is a crucial organ in energy metabolism and thermoregulation. Adipose
tissue phenotype is controlled by various signaling mechanisms under pathophysiological …

Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Q Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
Endometrial decidualization is a uterine process essential for spiral artery remodeling,
embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and …

Corin Deficiency Diminishes Intestinal Sodium Excretion in Mice

X Gu, K Wang, W Li, M He, T Zhou, M Liu, Q Wu… - Biology, 2023 - mdpi.com
Simple Summary Sodium homeostasis is critical for body fluid balance. The hormonal
regulation of sodium reabsorption and excretion is central in sodium homeostasis. The …

Renal corin is essential for normal blood pressure and sodium homeostasis

T Zhou, S Zhang, C Du, K Wang, X Gu, S Sun… - International Journal of …, 2022 - mdpi.com
Atrial natriuretic peptide (ANP)-mediated natriuresis is known as a cardiac endocrine
function in sodium and body fluid homeostasis. Corin is a protease essential for ANP …

[HTML][HTML] Corin deficiency impairs cardiac function in mouse models of heart failure

Y Niu, T Zhou, S Zhang, W Li, K Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Corin is a protease in the natriuretic peptide system. Deleterious CORIN
variants are associated with hypertension and heart disease. It remains unclear if and to …

Corin deficiency alters adipose tissue phenotype and impairs thermogenesis in mice

X Zhang, W Li, T Zhou, M Liu, Q Wu, N Dong - Biology, 2022 - mdpi.com
Simple Summary Thermoregulation is of fundamental significance for all endothermic
animals. Corin is a protease that activates atrial natriuretic peptide (ANP), a cardiac …

Corin deficiency alleviates mucosal lesions in a mouse model of colitis induced by dextran sulfate sodium

X Gu, M Liu, M Wang, K Wang, T Zhou, Q Wu, N Dong - Life Sciences, 2024 - Elsevier
Aims High dietary salt consumption is a risk factor for inflammatory bowel disease (IBD).
Corin is a protease that activates atrial natriuretic peptide (ANP), thereby regulating sodium …

A Galectin-9–Driven CD11chigh Decidual Macrophage Subset Suppresses Uterine Vascular Remodeling in Preeclampsia

Y Li, Y Sang, Y Chang, C Xu, Y Lin, Y Zhang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Preeclampsia is a serious disease of pregnancy that lacks early diagnosis
methods or effective treatment, except delivery. Dysregulated uterine immune cells and …