Uric acid, generated from the metabolism of purines, has proven and emerging roles in
human disease. Serum uric acid is determined by production and the net balance of …

Gout is a common and very painful inflammatory arthritis caused by hyperuricaemia. This
Review provides an update on the genetics of hyperuricaemia and gout, including findings …

Objective To assess the epidemiology of gout and hyperuricaemia in the Italian general
population during the years 2005–2009. Methods Using the Italian primary care database …

Gout is one of the most common inflammatory arthritides, caused by hyperuricemia, with an
increasing prevalence. Hyperuricemia is often a consequence of renal underexcretion of …

The tophus is the cardinal feature of advanced gout. This review summarises recent
research into the biology, impact and treatment of tophaceous gout. Microscopically, tophi …

Uric acid, the end product of purine metabolism, plays a key role in the pathogenesis of gout
and other disease processes. The circulating serum uric acid concentration is governed by …

SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys,
the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial …

Over the last decade, there have been major advances in the understanding of the genetic
basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering …

Urate is produced in the liver by the degradation of purines from the diet and nucleotide
turnover and excreted by the kidney and gut. The kidney is the major route of urate removal …

Objective Uric acid is the end product of purine metabolism in humans, and increased serum
uric acid concentrations lead to gout. The objective of the current study was to identify factors …