Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Lipoprotein (a) and its significance in cardiovascular disease: a review

FD Lau, RP Giugliano - Jama Cardiology, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is a low-density lipoprotein (LDL) cholesterol–like particle
bound to apolipoprotein (a). This novel marker of cardiovascular disease acts through …

Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein (a)

MJ Koren, PM Moriarty, SJ Baum, J Neutel… - Nature medicine, 2022 - nature.com
Compelling evidence supports a causal role for lipoprotein (a)(Lp (a)) in cardiovascular
disease. No pharmacotherapies directly targeting Lp (a) are currently available for clinical …

Lp (a)(lipoprotein [a]) concentrations and incident atherosclerotic cardiovascular disease: new insights from a large national biobank

AP Patel, M Wang, JP Pirruccello… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) concentrations are associated with atherosclerotic
cardiovascular disease (ASCVD), and new therapies that enable potent and specific …

Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

RE Mukamel, RE Handsaker, MA Sherman, AR Barton… - Science, 2021 - science.org
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …

A modern approach to dyslipidemia

AJ Berberich, RA Hegele - Endocrine reviews, 2022 - academic.oup.com
Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

Clinical utility of lipoprotein (a) and LPA genetic risk score in risk prediction of incident atherosclerotic cardiovascular disease

M Trinder, MM Uddin, P Finneran, KG Aragam… - JAMA …, 2021 - jamanetwork.com
Importance Lipoprotein (a) is a highly heritable biomarker independently associated with
atherosclerotic cardiovascular disease (ASCVD). It is unclear whether measured lipoprotein …

The dawn of a new era of targeted lipid-lowering therapies

L Tokgözoğlu, P Libby - European heart journal, 2022 - academic.oup.com
Lipid risk factors for cardiovascular disease depend in part on lifestyle, but optimum control
of lipids often demands additional measures. Low-density lipoprotein (LDL) doubtless …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …