Interaction Between Primary Hyperlipidemias and Type 2 Diabetes: Therapeutic Implications

R Zubirán, I Cruz-Bautista, CA Aguilar-Salinas - Diabetes Therapy, 2024 - Springer
There is a gap of knowledge about the clinical and pathophysiological implications resulting
from the interaction between primary hyperlipidemias and type 2 diabetes (T2D). Most of the …

Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic LPA Gene Expression Levels With Cardiovascular Outcomes …

J Guertin, Y Kaiser, H Manikpurage… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Elevated Lp (a)(Lipoprotein (a)) levels are associated with coronary artery
disease (CAD), ischemic stroke (IS), and calcific aortic valve stenosis (CAVS). Studies …

Lipoprotein (a) and diabetes mellitus: causes and consequences

NC Ward, S Vickneswaran… - Current Opinion in …, 2021 - journals.lww.com
Although Lp (a) contributes to the development of cardiovascular disease in patients with
diabetes, few trials have investigated the benefits of reducing Lp (a) within this patient …

Lipid-lowering biotechnological drugs: from monoclonal antibodies to antisense therapies—a clinical perspective

X Jia, J Liu, A Mehta, CM Ballantyne… - Cardiovascular drugs and …, 2021 - Springer
Purpose While low density lipoprotein cholesterol (LDL-C) remains a key contributor of
atherosclerotic cardiovascular disease (ASCVD), additional risk factors identified through …

Remnant-like particle cholesterol and the risk of major adverse cardiovascular events: a systematic review and meta-analysis

J Yang, Y Wang, Z Xi, Y Ma, C Shao, W Wang… - Journal of …, 2022 - mdpi.com
Background: The remnant-like particle cholesterol (RLP-C) has been demonstrated to be
associated with residual cardiovascular risk. The meta-analysis aimed to evaluate the …

Determinants of Lipid Parameters in Patients without Diagnosed Cardiovascular Disease—Results of the Polish Arm of the EUROASPIRE V Survey

J Ratajczak, A Kubica, P Michalski… - Journal of Clinical …, 2023 - mdpi.com
To assess the determinants of lipid parameters in primary care patients without diagnosed
cardiovascular disease (CVD), a cross-sectional study was conducted during 2018–2019 …

Contribution of Lipoprotein (a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis

HD Manikpurage, A Paulin, A Girard… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Lp (a)(lipoprotein [a]) is a highly atherogenic lipoprotein subfraction that may
contribute to polygenic risk of coronary artery disease (CAD), but the extent of this …

The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat

R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …

The lipid paradox in neuroprogressive disorders: causes and consequences

G Morris, M Berk, K Walder, A O'Neil, M Maes… - Neuroscience & …, 2021 - Elsevier
Chronic systemic inflammation is associated with an increased risk of cardiovascular
disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and …

Metabolic effect of blocking sodium-taurocholate Co-transporting polypeptide in hypercholesterolemic humans with a twelve-week course of bulevirtide—an …

F Stoll, A Seidel-Glätzer, I Burghaus, O Göring… - International Journal of …, 2022 - mdpi.com
Bile acids (BA) play an important role in cholesterol metabolism and possess further
beneficial metabolic effects as signalling molecules. Blocking the hepatocellular uptake of …