AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Biochemical, electrophysiological, and pharmacological evidence supporting a role for
cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt …

Both Alzheimer's disease (AD) and Type 2 diabetes mellitus (T2DM) share the presence of
systemic and neuro-inflammation, enhanced production and accumulation of β-amyloid …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently added diffusion
tensor imaging (DTI), among several other new imaging modalities, in an effort to identify …

Modulatory neurotransmitters which signal through G protein-coupled receptors control
brain functions which deteriorate in degenerative brain diseases. During the past decade …

BACKGROUND: The basal forebrain cholinergic system (BFCS) is known to undergo
moderate neurodegenerative changes during normal aging as well as severe atrophy in …

A deficiency in the noradrenergic system of the brain, originating largely from cells in the
locus coeruleus (LC), is theorized to play a critical role in the progression of a family of …

Deficits in cholinergic function contribute to the pathology of Alzheimer's disease (AD),
affecting cognition, behaviour and activities of daily living. Pharmacological intervention …

Acetylcholinesterase is an enzyme associated with senile plaques. Biochemical studies
have indicated that acetylcholinesterase induces amyloid fibril formation by interaction …

Due to the similarities in diffusion tensor imaging findings in both mild cognitive impairment
and Alzheimer's disease, it is likely that diffusion tensor imaging has the potential to emerge …