[HTML][HTML] Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics
Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …
[HTML][HTML] Cardiomyocyte death: mechanisms and translational implications
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Although treatments have improved, development of novel therapies for patients with CVD …
Although treatments have improved, development of novel therapies for patients with CVD …
Muscle oxygen transport and utilization in heart failure: implications for exercise (in) tolerance
The defining characteristic of chronic heart failure (CHF) is an exercise intolerance that is
inextricably linked to structural and functional aberrations in the O2 transport pathway. CHF …
inextricably linked to structural and functional aberrations in the O2 transport pathway. CHF …
[HTML][HTML] Harnessing tumor necrosis factor alpha to achieve effective cancer immunotherapy
MF Mercogliano, S Bruni, F Mauro, PV Elizalde… - Cancers, 2021 - mdpi.com
Simple Summary Inflammation has been acknowledged as one of the causes of increased
cancer risk. Among the pro-inflammatory mediators, tumor necrosis factor alpha (TNFα) has …
cancer risk. Among the pro-inflammatory mediators, tumor necrosis factor alpha (TNFα) has …
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17
L Grine, L Dejager, C Libert… - Cytokine & growth factor …, 2015 - Elsevier
Psoriasis is a skin disease where various cytokines play a detrimental role, yet our
understanding of the disease is still limited. TNF is a validated drug target in psoriasis and …
understanding of the disease is still limited. TNF is a validated drug target in psoriasis and …
Proinflammatory cytokines in heart failure: double-edged swords
Increased circulating and intracardiac levels of proinflammatory cytokines have been
associated with chronic heart failure. Following an initial insult, the increased production of …
associated with chronic heart failure. Following an initial insult, the increased production of …
Clinical pharmacokinetics and use of infliximab
U Klotz, A Teml, M Schwab - Clinical pharmacokinetics, 2007 - Springer
Tumor necrosis factor-α (TNFα) is a key proinflammatory cytokine involved in chronic
inflammatory diseases. Infliximab, a chimeric (human-murine) monoclonal IgG1 anti-TNFα …
inflammatory diseases. Infliximab, a chimeric (human-murine) monoclonal IgG1 anti-TNFα …
PPAR dual agonists: are they opening Pandora's Box?
P Balakumar, M Rose, SS Ganti, P Krishan… - Pharmacological …, 2007 - Elsevier
Cardiovascular disorders are the major cause of mortality in patients of diabetes mellitus.
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription …
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription …
Post-infectious group A streptococcal autoimmune syndromes and the heart
WJ Martin, AC Steer, PR Smeesters, J Keeble… - Autoimmunity …, 2015 - Elsevier
There is a pressing need to reduce the high global disease burden of rheumatic heart
disease (RHD) and its harbinger, acute rheumatic fever (ARF). ARF is a classical example of …
disease (RHD) and its harbinger, acute rheumatic fever (ARF). ARF is a classical example of …
Transcription factor NF-κB: an update on intervention strategies
The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic
molecules that regulate the expression of more than 150 genes involved in a broad range of …
molecules that regulate the expression of more than 150 genes involved in a broad range of …