Therapeutic resistance represents a major cause of death for most lethal cancers. However,
the underlying mechanisms of such resistance have remained unclear. The polyploid cells …

Cutaneous melanoma is an aggressive tumor; its incidence has been reported to increase
fast in the past decades. Melanoma is a heterogeneous tumor, with most patients harboring …

Melanoma is a malignant tumor with high rate of metastasis and poor prognosis. How
melanoma develops and how to treat it will continue to be a hot topic. This review briefly …

Disparities in the prognosis and incidence of melanoma between male and female patients
have led clinicians to explore the influence of steroid hormones on the development and …

The identification of intracellular signaling pathways that promote cell proliferation and
resistance to cell death may lead to the development of improved treatment for advanced …

Complete response (CR) rates reported for cytotoxic chemotherapy for late-stage cancer
patients are generally low, with few exceptions, regardless of the solid cancer type or drug …

In the present study, the toxicity of yperite, SM, and its structural analogue mechlorethamine,
HN2, was investigated in a human bronchial epithelial cell line 16HBE. Cell detachment was …

This review provides a review of the basic biology of the major cytokines under
consideration for use in tumor immunotherapy. The authors also describe the clinical role of …

The incidence of malignant melanoma is rising faster than any other malignancy. Although
earlier stage patients can be cured with surgical resection with or without adjuvant therapy, a …

Opinion statement As new and effective novel therapies in inflammatory bowel disease (IBD)
become available, patients are living longer with advancing age and are at increased risk for …