Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options
Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
The immune niche of the liver
The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …
Human NK cells: From development to effector functions
AS Perera Molligoda Arachchige - Innate immunity, 2021 - journals.sagepub.com
NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …
[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications
C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …
Mapping functional humoral correlates of protection against malaria challenge following RTS, S/AS01 vaccination
TJ Suscovich, JK Fallon, J Das, AR Demas… - Science translational …, 2020 - science.org
Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …
immunology analyses and controlled human infection models to define the protective …
Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma
C Zheng, BE Snow, AJ Elia, R Nechanitzky… - Nature Cancer, 2023 - nature.com
Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other
visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It …
visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It …
Immune–metabolic interactions in homeostasis and the progression to NASH
JA Hoogerland, B Staels, D Dombrowicz - Trends in Endocrinology & …, 2022 - cell.com
The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …
Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond
E Shin, SH Bak, T Park, JW Kim, SR Yoon… - Frontiers in …, 2023 - frontiersin.org
Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …
A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC
K Du, Y Li, J Liu, W Chen, Z Wei, Y Luo, H Liu, Y Qi… - Molecular Therapy, 2021 - cell.com
Glypican-3 (GPC3) is a well-characterized hepatocellular carcinoma (HCC)-associated
antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 is a …
antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 is a …
Predictive factors for response to PD-1/PD-L1 checkpoint inhibition in the field of hepatocellular carcinoma: current status and challenges
Z Macek Jilkova, C Aspord, T Decaens - Cancers, 2019 - mdpi.com
Immunotherapies targeting immune checkpoints are fast-developing therapeutic
approaches adopted for several tumor types that trigger unprecedented rates of durable …
approaches adopted for several tumor types that trigger unprecedented rates of durable …