The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

NK cells are the major lymphocyte subset of the innate immune system that mediates
antiviral and anti-tumor responses. It is well established that they develop mechanisms to …

Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Vaccine development has the potential to be accelerated by coupling tools such as systems
immunology analyses and controlled human infection models to define the protective …

Cholinergic nerves are involved in tumor progression and dissemination. In contrast to other
visceral tissues, cholinergic innervation in the hepatic parenchyma is poorly detected. It …

The incidence of non-alcoholic fatty liver disease (NAFLD) has increased significantly over
the past two decades. NAFLD ranges from simple steatosis (NAFL) to nonalcoholic …

Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Glypican-3 (GPC3) is a well-characterized hepatocellular carcinoma (HCC)-associated
antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 is a …

Immunotherapies targeting immune checkpoints are fast-developing therapeutic
approaches adopted for several tumor types that trigger unprecedented rates of durable …